Camilla Forsberg

Where does blood come from?

The Forsberg lab focuses on stem cell fate decisions of the blood system. Hematopoietic stem cells are responsible for generating a life-long supply of mature blood cells. Each stem cell is capable of making all of the mature blood cell types with widely different functions: some blood cells specialize in carrying oxygen, others fight off infections, and still others prevent bleeding in the process of blood clotting. How does a stem cell decide which cell type to give rise to? Are these decisions made by the stem cell itself, by its descendant multipotent progenitors, or both? How are these decisions dysregulated to cause cancer and other disorders?

We tackle these questions from multiple angles - by in vivo and in vitro experimental approaches, by focusing on specific molecules as well as analyzing global changes. Ultimately, we want to understand the molecular determinants of hematopoietic stem cell fate decisions so that we can prevent and treat both genetic and acquired disorders of the hematopoietic system, including anemia, autoimmune disease, leukemias and lymphomas.

 Postdoctoral positions available



* = Forsberg lab member


Selected for “Faculty of 1000” 

Cover imageRobo4
Comment in: Cell Stem Cell 2011 Jan 7;8(1):6-7. Moore K. “A roundabout way to the niche”
Comment in: Nature 2011 Jan 20; 469(7330). Research Highlights, “Stem cells: Robo protein guide for cell transplants”
Selected for “Faculty of 1000” 

  • Chang, E.1, Forsberg, E.C.1, Wu, J., Wang, B., Prohaska, S.S1., Allsopp, R., Weissman, I.L., and Cooke, J.P. (2010) Cholinergic activation of hematopoietic stem cells. Vasc Med. Oct;15(5):375- 85.

  • Marlow, R., Binnewies, M., Monica, S., Strickland, P., Forsberg, E.C., Li, D.Y., and Hinck, L. (2010) Vascular Robo4 restricts pro-angiogenic epithelial signaling in breast. Proc. Natl. Acad. Sci. U.S.A. 107(23):10520-5. Epub 2010 May 24.

  • Santaguida, M., Schepers, K., King, B., Sabnis, A.J., Forsberg, E.C., Attema, J.L., Braun, B.S., and Passegué, E. (2009). JunB protects against myeloid malignancies by limiting hematopoietic stem cell proliferation and differentiation without affecting self-renewal. Cancer Cell, 5: 341-52.

  • *Forsberg, E.C. and *Smith-Berdan, S. (2009) Parsing the niche code: the molecular mechanisms governing hematopoietic stem cell adhesion and differentiation. Haematologica 94(11):1477-81.  Parsing

Cover image

  • Forsberg, E.C., Passegue, E1., Prohaska, S.S1., Wagers, A.J1., Koeva, M., Stuart, J.M., and Weissman, I.L. (2009) Molecular signatures of quiescent and mobilized hematopoietic stem cells and leukemic stem cells. PLoS One Jan 20;5(1):e8785.
  • Ooi, A.G.L., Karsunky, H., Majeti, R., Butz, S., Vestweber, D., Ishida, T., Quertermous, T., Weissman, I.L., and Forsberg, E.C. (2008) The adhesion molecule ESAM1 is a selective marker for hematopoietic stem cells. Stem Cells. 2008 Dec 11, Epub ahead of print.
  • Attema JL, Papathanasiou P, Forsberg EC, Xu J, Smale ST, Weissman IL. Epigenetic characterization of hematopoietic stem cell differentiation using miniChIP and bisulfite sequencing analysis. Proc Natl Acad Sci U S A. 2007 Jul 24;104(30):12371-6. Epub 2007 Jul 18.
  • Forsberg EC, Bhattacharya D, Weissman IL. Hematopoietic stem cells: expression profiling and beyond. Stem Cell Rev. 2006;2(1):23-30. Review.
  • Forsberg EC, Serwold T, Kogan S, Weissman IL, Passegué E. New evidence supporting megakaryocyte-erythrocyte potential of flk2/flt3+ multipotent hematopoietic progenitors. Cell. 2006 Jul 28;126(2):415-26.
  • Forsberg EC, Prohaska SS, Katzman S, Heffner GC, Stuart JM, Weissman IL. Differential expression of novel potential regulators in hematopoietic stem cells. PLoS Genet. 2005 Sep;1(3):e28.